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Active unfolding of the glucocorticoid receptor by the Hsp70/Hsp40 chaperone system in single-molecule mechanical experiments

Active unfolding of the glucocorticoid receptor by the Hsp70/Hsp40 chaperone system in single-molecule mechanical experiments

Publication

Title of Publication
Active unfolding of the glucocorticoid receptor by the Hsp70/Hsp40 chaperone system in single-molecule mechanical experiments
Publication Year
2022
Authors
Moessmer P, Suren T, Majdic U, Dahiya V, Rutz D, Buchner J, Rief M.
Journal
Proc Natl Acad Sci U S A
DOI
https://doi.org/10.1073/pnas.2119076119

Construct

Construct Name
GR-LBD: (residues: 521-777)
Gene Name
glucocorticoid receptor (GR)
Sequence
SACKQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVK WAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLII NEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKS QELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYC FQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIK KLLFHQKCL